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This is The N of 1, a brand new site by M. Vafa that's just getting started. Things will be up and running here shortly, but you can subscribe in the meantime if you'd like to stay up to date and receive emails when new content

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Ketamine's DMN Reset: Proving the Self Was Never There

TL;DR Ketamine doesn't heal depression—it temporarily deletes you by disrupting the default mode network (DMN), the brain's self-generating machinery. By severing connections between the posterior cingulate cortex and medial prefrontal cortex, it reveals what consciousness researchers and Buddhists have long suspected: the self is

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